Thymoquinone Potentiates the Effect of Phenytoin against Electroshock-Induced Convulsions in Rats by Reducing the Hyperactivation of m-TOR Pathway and Neuroinflammation: Evidence from In Vivo, In Vitro and Computational Studies

Epilepsy is a chronic neurodegenerative disease characterized by multiple seizures, hereto 35% of patients remain poor responders. Phenytoin (PHT; 20 and 40 mg/kg) and thymoquinone (THQ; 40 and 80 mg/kg) were given alone and as a low dose combination for 14 days (p.o), prior to challenge with maxima...

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Detalles Bibliográficos
Autores principales: Pottoo, Faheem Hyder, Salahuddin, Mohammed, Khan, Firdos Alam, Alomar, Fadhel, AL Dhamen, Marwa Abdullah, Alhashim, Abrar Fouad, Alqattan, Hawra Hussain, Gomaa, Mohamed S., Alomary, Mohammad N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618888/
https://www.ncbi.nlm.nih.gov/pubmed/34832914
http://dx.doi.org/10.3390/ph14111132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618888/
https://www.ncbi.nlm.nih.gov/pubmed/34832914
http://dx.doi.org/10.3390/ph14111132

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