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Thymoquinone Potentiates the Effect of Phenytoin against Electroshock-Induced Convulsions in Rats by Reducing the Hyperactivation of m-TOR Pathway and Neuroinflammation: Evidence from In Vivo, In Vitro and Computational Studies
Epilepsy is a chronic neurodegenerative disease characterized by multiple seizures, hereto 35% of patients remain poor responders. Phenytoin (PHT; 20 and 40 mg/kg) and thymoquinone (THQ; 40 and 80 mg/kg) were given alone and as a low dose combination for 14 days (p.o), prior to challenge with maxima...
Autores principales: | Pottoo, Faheem Hyder, Salahuddin, Mohammed, Khan, Firdos Alam, Alomar, Fadhel, AL Dhamen, Marwa Abdullah, Alhashim, Abrar Fouad, Alqattan, Hawra Hussain, Gomaa, Mohamed S., Alomary, Mohammad N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618888/ https://www.ncbi.nlm.nih.gov/pubmed/34832914 http://dx.doi.org/10.3390/ph14111132 |
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