Discovery of New Ginsenol-Like Compounds with High Antiviral Activity

A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which...

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Autores principales: Volobueva, Aleksandrina S., Yarovaya, Olga I., Kireeva, Marina V., Borisevich, Sophia S., Kovaleva, Kseniya S., Mainagashev, Iliya Ya., Gatilov, Yuri V., Ilyina, Margarita G., Zarubaev, Vladimir V., Salakhutdinov, Nariman F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619001/
https://www.ncbi.nlm.nih.gov/pubmed/34833886
http://dx.doi.org/10.3390/molecules26226794
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author Volobueva, Aleksandrina S.
Yarovaya, Olga I.
Kireeva, Marina V.
Borisevich, Sophia S.
Kovaleva, Kseniya S.
Mainagashev, Iliya Ya.
Gatilov, Yuri V.
Ilyina, Margarita G.
Zarubaev, Vladimir V.
Salakhutdinov, Nariman F.
author_facet Volobueva, Aleksandrina S.
Yarovaya, Olga I.
Kireeva, Marina V.
Borisevich, Sophia S.
Kovaleva, Kseniya S.
Mainagashev, Iliya Ya.
Gatilov, Yuri V.
Ilyina, Margarita G.
Zarubaev, Vladimir V.
Salakhutdinov, Nariman F.
author_sort Volobueva, Aleksandrina S.
collection PubMed
description A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus.
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spelling pubmed-86190012021-11-27 Discovery of New Ginsenol-Like Compounds with High Antiviral Activity Volobueva, Aleksandrina S. Yarovaya, Olga I. Kireeva, Marina V. Borisevich, Sophia S. Kovaleva, Kseniya S. Mainagashev, Iliya Ya. Gatilov, Yuri V. Ilyina, Margarita G. Zarubaev, Vladimir V. Salakhutdinov, Nariman F. Molecules Article A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus. MDPI 2021-11-10 /pmc/articles/PMC8619001/ /pubmed/34833886 http://dx.doi.org/10.3390/molecules26226794 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Volobueva, Aleksandrina S.
Yarovaya, Olga I.
Kireeva, Marina V.
Borisevich, Sophia S.
Kovaleva, Kseniya S.
Mainagashev, Iliya Ya.
Gatilov, Yuri V.
Ilyina, Margarita G.
Zarubaev, Vladimir V.
Salakhutdinov, Nariman F.
Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_full Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_fullStr Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_full_unstemmed Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_short Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_sort discovery of new ginsenol-like compounds with high antiviral activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619001/
https://www.ncbi.nlm.nih.gov/pubmed/34833886
http://dx.doi.org/10.3390/molecules26226794
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