A Study on Synthesis and Upscaling of 2′-O-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis

2′-O-(N-(Aminoethyl)carbamoyl)methyl-modified 5-methyluridine (AECM-MeU) and 5-methylcytidine (AECM-MeC) phosphoramidites are reported for the first time and prepared in multigram quantities. The syntheses of AECM-MeU and AECM-MeC nucleosides are designed for larger scales (approx. 20 g up until pho...

Descripción completa

Detalles Bibliográficos
Autores principales: Karalė, Kristina, Bollmark, Martin, Stulz, Rouven, Honcharenko, Dmytro, Tedebark, Ulf, Strömberg, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619030/
https://www.ncbi.nlm.nih.gov/pubmed/34834019
http://dx.doi.org/10.3390/molecules26226927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619030/
https://www.ncbi.nlm.nih.gov/pubmed/34834019
http://dx.doi.org/10.3390/molecules26226927

Ejemplares similares