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Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na(+) Channel 1.2 Macromolecular Complex

Voltage-gated Na(+) (Na(v)) channels are a primary molecular determinant of the action potential (AP). Despite the canonical role of the pore-forming α subunit in conferring this function, protein–protein interactions (PPI) between the Na(v) channel α subunit and its auxiliary proteins are necessary...

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Detalles Bibliográficos
Autores principales: Dvorak, Nolan M., Tapia, Cynthia M., Baumgartner, Timothy J., Singh, Jully, Laezza, Fernanda, Singh, Aditya K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619224/
https://www.ncbi.nlm.nih.gov/pubmed/34831326
http://dx.doi.org/10.3390/cells10113103