Cargando…

Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na(+) Channel 1.2 Macromolecular Complex

Voltage-gated Na(+) (Na(v)) channels are a primary molecular determinant of the action potential (AP). Despite the canonical role of the pore-forming α subunit in conferring this function, protein–protein interactions (PPI) between the Na(v) channel α subunit and its auxiliary proteins are necessary...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dvorak, Nolan M., Tapia, Cynthia M., Baumgartner, Timothy J., Singh, Jully, Laezza, Fernanda, Singh, Aditya K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619224/ https://www.ncbi.nlm.nih.gov/pubmed/34831326 http://dx.doi.org/10.3390/cells10113103

Ejemplares similares

Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na(+) Channel 1.6 Enables Isoform-Selective Modulation
por: Dvorak, Nolan M., et al.
Publicado: (2021)

Differential Modulation of the Voltage-Gated Na(+) Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14
por: Singh, Aditya K., et al.
Publicado: (2021)

Voltage-Gated Na(+) Channels in Alzheimer’s Disease: Physiological Roles and Therapeutic Potential
por: Baumgartner, Timothy J., et al.
Publicado: (2023)

Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics
por: Dvorak, Nolan M., et al.
Publicado: (2020)

High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na(+) channel complex
por: Wadsworth, Paul A., et al.
Publicado: (2019)

Quantitative Proteomics Reveals Protein–Protein Interactions with Fibroblast Growth Factor 12 as a Component of the Voltage-Gated Sodium Channel 1.2 (Nav1.2) Macromolecular Complex in Mammalian Brain
por: Wildburger, Norelle C., et al.
Publicado: (2015)

Inhibition of the Akt/PKB Kinase Increases Na(v)1.6-Mediated Currents and Neuronal Excitability in CA1 Hippocampal Pyramidal Neurons
por: Marosi, Mate, et al.
Publicado: (2022)

Voltage-dependent gating of veratridine-modified Na channels
Publicado: (1986)

Mechanism of μ-Conotoxin PIIIA Binding to the Voltage-Gated Na(+) Channel Na(V)1.4
por: Chen, Rong, et al.
Publicado: (2014)

Electrophysiological and Pharmacological Analyses of Na(v)1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System
por: Zhou, Xi, et al.
Publicado: (2017)

The Voltage-Gated Sodium Channel Na(v)1.8 Is Expressed in Human Sperm
por: Cejudo-Roman, Antonio, et al.
Publicado: (2013)

The voltage-gated sodium channel Na(v)1.7 associated with endometrial cancer
por: Liu, Junxiu, et al.
Publicado: (2019)

Life Cycle of the Cardiac Voltage-Gated Sodium Channel Na(V)1.5
por: Dong, Caijuan, et al.
Publicado: (2020)

Calmodulin and Ca(2+) control of voltage gated Na(+) channels
por: Gabelli, Sandra B, et al.
Publicado: (2015)

Differential Sialylation Modulates Voltage-gated Na(+) Channel Gating throughout the Developing Myocardium
por: Stocker, Patrick J., et al.
Publicado: (2006)

The Position of the Fast-Inactivation Gate during Lidocaine Block of Voltage-gated Na(+) Channels
por: Vedantham, Vasanth, et al.
Publicado: (1999)

Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways
por: Dongol, Yashad, et al.
Publicado: (2019)

Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Na(v)1.7 and Na(v)1.5
por: Bok, Chan-Su, et al.
Publicado: (2023)

Cryo-EM structure of human voltage-gated sodium channel Na(v)1.6
por: Fan, Xiao, et al.
Publicado: (2023)

Preferential Targeting of Na(v)1.6 Voltage-Gated Na(+) Channels to the Axon Initial Segment during Development
por: Akin, Elizabeth J., et al.
Publicado: (2015)

Voltage-Gated Sodium Channels: Biophysics, Pharmacology, and Related Channelopathies
por: Savio-Galimberti, Eleonora, et al.
Publicado: (2012)

Lysine and the Na(+)/K(+) Selectivity in Mammalian Voltage-Gated Sodium Channels
por: Li, Yang, et al.
Publicado: (2016)

Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
por: Rhana, P., et al.
Publicado: (2017)

Voltage-Gated K(+)/Na(+) Channels and Scorpion Venom Toxins in Cancer
por: Díaz-García, Alexis, et al.
Publicado: (2020)

A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na(+) Channels
por: Liu, Yichen, et al.
Publicado: (2023)

A mechanistic reinterpretation of fast inactivation in voltage-gated Na(+) channels
por: Liu, Yichen, et al.
Publicado: (2023)

A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na(+) Channels
por: Liu, Yichen, et al.
Publicado: (2023)

Slow Inactivation Does Not Affect Movement of the Fast Inactivation Gate in Voltage-gated Na(+) Channels
por: Vedantham, Vasanth, et al.
Publicado: (1998)

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na(+) Channel with 4-Fold Symmetry
por: Balasuriya, Dilshan, et al.
Publicado: (2012)

Na(V)1.6 and Na(V)1.7 channels are major endogenous voltage-gated sodium channels in ND7/23 cells
por: Lee, Jisoo, et al.
Publicado: (2019)

Structural Basis for the Modulation of the Neuronal Voltage-Gated Sodium Channel Na(V)1.6 by Calmodulin
por: Chichili, Vishnu Priyanka Reddy, et al.
Publicado: (2013)

Na(v)1.7 and other voltage-gated sodium channels as drug targets for pain relief
por: Emery, Edward C, et al.
Publicado: (2016)

µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype Na(V)1.7
por: McMahon, Kirsten L., et al.
Publicado: (2022)

Scanning mutagenesis of the voltage-gated sodium channel Na(V)1.2 using base editing
por: Pablo, Juan Lorenzo B., et al.
Publicado: (2023)

Development of high-affinity nanobodies specific for Na(V)1.4 and Na(V)1.5 voltage-gated sodium channel isoforms
por: Srinivasan, Lakshmi, et al.
Publicado: (2022)

Gating of the Bacterial Sodium Channel, NaChBac: Voltage-dependent Charge Movement and Gating Currents
por: Kuzmenkin, Alexey, et al.
Publicado: (2004)

Recent advances in voltage-gated sodium channels, their pharmacology, and related diseases
por: Desaphy, Jean-François, et al.
Publicado: (2013)

The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels
por: Alexander, Stephen PH, et al.
Publicado: (2015)

Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology
por: Dolphin, Annette C.
Publicado: (2016)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage‐gated ion channels
por: Alexander, Stephen PH, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_upek522q371m74f81etmuammit