Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study

Human α-defensin 5 (HD5) is a host-defense peptide exhibiting broad-spectrum antimicrobial activity. The lipopolysaccharide (LPS) layer on the Gram-negative bacterial membrane acts as a barrier to HD5 insertion. Therefore, the pore formation and binding mechanism remain unclear. Here, the binding me...

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Detalles Bibliográficos
Autores principales: Awang, Tadsanee, Chairatana, Phoom, Vijayan, Ranjit, Pongprayoon, Prapasiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619297/
https://www.ncbi.nlm.nih.gov/pubmed/34830284
http://dx.doi.org/10.3390/ijms222212401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619297/
https://www.ncbi.nlm.nih.gov/pubmed/34830284
http://dx.doi.org/10.3390/ijms222212401

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