Cargando…

Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study

Human α-defensin 5 (HD5) is a host-defense peptide exhibiting broad-spectrum antimicrobial activity. The lipopolysaccharide (LPS) layer on the Gram-negative bacterial membrane acts as a barrier to HD5 insertion. Therefore, the pore formation and binding mechanism remain unclear. Here, the binding me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Awang, Tadsanee, Chairatana, Phoom, Vijayan, Ranjit, Pongprayoon, Prapasiri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619297/ https://www.ncbi.nlm.nih.gov/pubmed/34830284 http://dx.doi.org/10.3390/ijms222212401

Ejemplares similares

Molecular dynamics simulations of human α-defensin 5 (HD5) crossing gram-negative bacterial membrane
por: Awang, Tadsanee, et al.
Publicado: (2023)

Structural insights into betaine aldehyde dehydrogenase (BADH2) from Oryza sativa explored by modeling and simulations
por: Baicharoen, Apisara, et al.
Publicado: (2018)

Molecular Basis for Self-Assembly of a Human Host-Defense Peptide That Entraps Bacterial Pathogens
por: Chairatana, Phoom, et al.
Publicado: (2014)

Proteolysis triggers self-assembly and unmasks innate immune function of a human α-defensin peptide
por: Chairatana, Phoom, et al.
Publicado: (2016)

Binding of Apo and Glycated Human Serum Albumins to an Albumin-Selective Aptamer-Bound Graphene Quantum Dot Complex
por: Sittiwanichai, Sirin, et al.
Publicado: (2023)

Binding Modes of Carnostatine, Homocarnosine, and Ophidine to Human Carnosinase 1
por: Toviwek, Borvornwat, et al.
Publicado: (2023)

Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli
por: Chairatana, Phoom, et al.
Publicado: (2015)

Modeling the Adsorption of the miR-29a Cancer Biomarker on a Graphene Quantum Dot
por: Kuntip, Nattapon, et al.
Publicado: (2021)

Observing How Glutathione and S-Hexyl Glutathione Bind to Glutathione S-Transferase from Rhipicephalus (Boophilus) microplus
por: Rangubpit, Warin, et al.
Publicado: (2022)

Assessment of Biofilm Formation by Candida albicans Strains Isolated from Hemocultures and Their Role in Pathogenesis in the Zebrafish Model
por: Pokhrel, Sabi, et al.
Publicado: (2022)

Antiviral Mechanisms of Human Defensins
por: Wilson, Sarah S., et al.
Publicado: (2013)

Molecular Dynamics Simulation Study of the Interaction between Human Angiotensin Converting Enzyme 2 and Spike Protein Receptor Binding Domain of the SARS-CoV-2 B.1.617 Variant
por: Antony, Priya, et al.
Publicado: (2021)

Cervicovaginal levels of human beta defensins during bacterial vaginosis
por: Noda-Nicolau, Nathalia Mayumi, et al.
Publicado: (2021)

Evaluating the Value of Defensins for Diagnosing Secondary Bacterial Infections in Influenza-Infected Patients
por: Zhou, Siyu, et al.
Publicado: (2018)

Combining flagellin and human β-defensin-3 to combat bacterial infections
por: Sabag, Ofra, et al.
Publicado: (2014)

Dynamics of camel and human hemoglobin revealed by molecular simulations
por: Ali, Amanat, et al.
Publicado: (2022)

Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action
por: Kling, Carolin, et al.
Publicado: (2023)

Mechanisms and regulation of defensins in host defense
por: Fu, Jie, et al.
Publicado: (2023)

Multifaceted immune functions of human defensins and underlying mechanisms
por: Fruitwala, Saahil, et al.
Publicado: (2018)

Effects of Boric Acid and Storage Temperature on the Analysis of Microalbumin Using Aptasensor-Based Fluorescent Detection
por: Sompark, Chalermwoot, et al.
Publicado: (2022)

β-Defensins Coordinate In Vivo to Inhibit Bacterial Infections of the Trachea
por: Ryan, Lisa Kathleen, et al.
Publicado: (2018)

Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection
por: Lehmann, Jan, et al.
Publicado: (2002)

Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing
por: Mathew, Basil, et al.
Publicado: (2017)

Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics
por: Hein, Matthew J. A., et al.
Publicado: (2022)

Antifungal Plant Defensins: Mechanisms of Action and Production
por: Vriens, Kim, et al.
Publicado: (2014)

Characterization of peptide binding to the SARS-CoV-2 host factor neuropilin
por: Jobe, Amie, et al.
Publicado: (2021)

Albuminuria detection using graphene oxide-mediated fluorescence quenching aptasensor
por: Chawjiraphan, Wireeya, et al.
Publicado: (2020)

Identification of Novel Aldose Reductase Inhibitors from Spices: A Molecular Docking and Simulation Study
por: Antony, Priya, et al.
Publicado: (2015)

Human Alpha Defensin 5 Expression in the Human Kidney and Urinary Tract
por: Spencer, John David, et al.
Publicado: (2012)

Human β-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate–mediated membrane permeabilization
por: Järvå, Michael, et al.
Publicado: (2018)

Human β‐defensin 3 increases the TLR9‐dependent response to bacterial DNA
por: McGlasson, Sarah L., et al.
Publicado: (2017)

Defensins and Sepsis
por: Xie, Guo-Hao, et al.
Publicado: (2014)

Avian defensins
por: van Dijk, Albert, et al.
Publicado: (2008)

Evaluation of human β‑defensins in the cerebrospinal fluid of suspected meningitis
por: Jaleel, Lena K., et al.
Publicado: (2022)

Analysis of mutations of defensin protein using accelerated molecular dynamics simulations
por: Pandey, Bharati, et al.
Publicado: (2020)

Human Peptides α-Defensin-1 and -5 Inhibit Pertussis Toxin
por: Kling, Carolin, et al.
Publicado: (2021)

Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD
por: Arnason, Jason W., et al.
Publicado: (2017)

Molecular Dynamics Simulations of Human Beta-Defensin Type 3 Crossing Different Lipid Bilayers
por: Yeasmin, Rabeta, et al.
Publicado: (2021)

Anti-HIV Activity of Human Defensin 5 in Primary CD4+ T Cells under Serum-Deprived Conditions Is a Consequence of Defensin-Mediated Cytotoxicity
por: Ding, Jian, et al.
Publicado: (2013)

Towards the Application of Human Defensins as Antivirals
por: Park, Mee Sook, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hi27nt37o5ih789brav4nh43ah