Generation and Characterization of the Drosophila melanogaster paralytic Gene Knock-Out as a Model for Dravet Syndrome

Dravet syndrome is a severe rare epileptic disease caused by mutations in the SCN1A gene coding for the Nav1.1 protein, a voltage-gated sodium channel alpha subunit. We have made a knock-out of the paralytic gene, the single Drosophila melanogaster gene encoding this type of protein, by homologous r...

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Detalles Bibliográficos
Autores principales: Tapia, Andrea, Giachello, Carlo N., Palomino-Schätzlein, Martina, Baines, Richard A., Galindo, Máximo Ibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619338/
https://www.ncbi.nlm.nih.gov/pubmed/34833136
http://dx.doi.org/10.3390/life11111261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619338/
https://www.ncbi.nlm.nih.gov/pubmed/34833136
http://dx.doi.org/10.3390/life11111261

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