The Antileukemic Effect of Xestoquinone, A Marine-Derived Polycyclic Quinone-Type Metabolite, Is Mediated through ROS-Induced Inhibition of HSP-90

Xestoquinone is a polycyclic quinone-type metabolite with a reported antitumor effect. We tested the cytotoxic activity of xestoquinone on a series of hematological cancer cell lines. The antileukemic effect of xestoquinone was evaluated in vitro and in vivo. This marine metabolite suppressed the pr...

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Detalles Bibliográficos
Autores principales: Wang, Kuan-Chih, Lu, Mei-Chin, Hsu, Kai-Cheng, El-Shazly, Mohamed, Shih, Shou-Ping, Lien, Ssu-Ting, Kuo, Fu-Wen, Yang, Shyh-Chyun, Chen, Chun-Lin, Yang, Yu-Chen S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619641/
https://www.ncbi.nlm.nih.gov/pubmed/34834129
http://dx.doi.org/10.3390/molecules26227037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619641/
https://www.ncbi.nlm.nih.gov/pubmed/34834129
http://dx.doi.org/10.3390/molecules26227037

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