Hydroxyurea Induces Bone Marrow Mesenchymal Stromal Cells Senescence and Modifies Cell Functionality In Vitro

Hydroxyurea (HU) is an antineoplastic agent that functions as an antimetabolite compound by inhibiting the ribonucleotide reductase. HU acts mainly as a cytostatic drug that through DNA replication stress may trigger a premature senescence-like cell phenotype, though its influence on bone marrow-der...

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Detalles Bibliográficos
Autores principales: Kapor, Sunčica, Vukotić, Milica, Subotički, Tijana, Đikić, Dragoslava, Mitrović Ajtić, Olivera, Radojković, Milica, Čokić, Vladan P., Santibanez, Juan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619969/
https://www.ncbi.nlm.nih.gov/pubmed/34834400
http://dx.doi.org/10.3390/jpm11111048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619969/
https://www.ncbi.nlm.nih.gov/pubmed/34834400
http://dx.doi.org/10.3390/jpm11111048

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