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Intratumoral Heterogeneity Promotes Collective Cancer Invasion through NOTCH1 Variation

Cellular and molecular heterogeneity within tumors has long been associated with the progression of cancer to an aggressive phenotype and a poor prognosis. However, how such intratumoral heterogeneity contributes to the invasiveness of cancer is largely unknown. Here, using a tumor bioengineering ap...

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Detalles Bibliográficos
Autores principales: Torab, Peter, Yan, Yue, Ahmed, Mona, Yamashita, Hironobu, Warrick, Joshua I., Raman, Jay D., DeGraff, David J., Wong, Pak Kin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619970/
https://www.ncbi.nlm.nih.gov/pubmed/34831307
http://dx.doi.org/10.3390/cells10113084