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The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers

Dietary nutrition intake is essential for human beings and influences various physiological and pathological actions in the human body. Among various nutritional factors, dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to have various beneficial effects against inflammat...

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Detalles Bibliográficos
Autores principales: Minokawa, Yoko, Sawada, Yu, Nakamura, Motonobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620049/
https://www.ncbi.nlm.nih.gov/pubmed/34829495
http://dx.doi.org/10.3390/diagnostics11112149
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author Minokawa, Yoko
Sawada, Yu
Nakamura, Motonobu
author_facet Minokawa, Yoko
Sawada, Yu
Nakamura, Motonobu
author_sort Minokawa, Yoko
collection PubMed
description Dietary nutrition intake is essential for human beings and influences various physiological and pathological actions in the human body. Among various nutritional factors, dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to have various beneficial effects against inflammatory diseases. In addition to their therapeutic potency against inflammation, omega-3 PUFAs have also been shown to have anti-tumor effects via various mechanisms, such as cell arrest and apoptosis. To date, limited information is available on these effects in cutaneous malignancies. In this review, we focused on the effect of omega-3 PUFAs on skin cancers, especially malignant melanoma, basal cell carcinoma, lymphoma, and squamous cell carcinoma and discussed the detailed molecular mechanism of the omega-3 PUFA-mediated anti-tumor response. We also explored the molecular mechanisms mediated by epigenetic modifications, cell adhesion molecules, and anti-tumor immune responses.
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spelling pubmed-86200492021-11-27 The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers Minokawa, Yoko Sawada, Yu Nakamura, Motonobu Diagnostics (Basel) Review Dietary nutrition intake is essential for human beings and influences various physiological and pathological actions in the human body. Among various nutritional factors, dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to have various beneficial effects against inflammatory diseases. In addition to their therapeutic potency against inflammation, omega-3 PUFAs have also been shown to have anti-tumor effects via various mechanisms, such as cell arrest and apoptosis. To date, limited information is available on these effects in cutaneous malignancies. In this review, we focused on the effect of omega-3 PUFAs on skin cancers, especially malignant melanoma, basal cell carcinoma, lymphoma, and squamous cell carcinoma and discussed the detailed molecular mechanism of the omega-3 PUFA-mediated anti-tumor response. We also explored the molecular mechanisms mediated by epigenetic modifications, cell adhesion molecules, and anti-tumor immune responses. MDPI 2021-11-19 /pmc/articles/PMC8620049/ /pubmed/34829495 http://dx.doi.org/10.3390/diagnostics11112149 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Minokawa, Yoko
Sawada, Yu
Nakamura, Motonobu
The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_full The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_fullStr The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_full_unstemmed The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_short The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_sort influences of omega-3 polyunsaturated fatty acids on the development of skin cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620049/
https://www.ncbi.nlm.nih.gov/pubmed/34829495
http://dx.doi.org/10.3390/diagnostics11112149
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