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The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
Dietary nutrition intake is essential for human beings and influences various physiological and pathological actions in the human body. Among various nutritional factors, dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to have various beneficial effects against inflammat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620049/ https://www.ncbi.nlm.nih.gov/pubmed/34829495 http://dx.doi.org/10.3390/diagnostics11112149 |
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author | Minokawa, Yoko Sawada, Yu Nakamura, Motonobu |
author_facet | Minokawa, Yoko Sawada, Yu Nakamura, Motonobu |
author_sort | Minokawa, Yoko |
collection | PubMed |
description | Dietary nutrition intake is essential for human beings and influences various physiological and pathological actions in the human body. Among various nutritional factors, dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to have various beneficial effects against inflammatory diseases. In addition to their therapeutic potency against inflammation, omega-3 PUFAs have also been shown to have anti-tumor effects via various mechanisms, such as cell arrest and apoptosis. To date, limited information is available on these effects in cutaneous malignancies. In this review, we focused on the effect of omega-3 PUFAs on skin cancers, especially malignant melanoma, basal cell carcinoma, lymphoma, and squamous cell carcinoma and discussed the detailed molecular mechanism of the omega-3 PUFA-mediated anti-tumor response. We also explored the molecular mechanisms mediated by epigenetic modifications, cell adhesion molecules, and anti-tumor immune responses. |
format | Online Article Text |
id | pubmed-8620049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86200492021-11-27 The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers Minokawa, Yoko Sawada, Yu Nakamura, Motonobu Diagnostics (Basel) Review Dietary nutrition intake is essential for human beings and influences various physiological and pathological actions in the human body. Among various nutritional factors, dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to have various beneficial effects against inflammatory diseases. In addition to their therapeutic potency against inflammation, omega-3 PUFAs have also been shown to have anti-tumor effects via various mechanisms, such as cell arrest and apoptosis. To date, limited information is available on these effects in cutaneous malignancies. In this review, we focused on the effect of omega-3 PUFAs on skin cancers, especially malignant melanoma, basal cell carcinoma, lymphoma, and squamous cell carcinoma and discussed the detailed molecular mechanism of the omega-3 PUFA-mediated anti-tumor response. We also explored the molecular mechanisms mediated by epigenetic modifications, cell adhesion molecules, and anti-tumor immune responses. MDPI 2021-11-19 /pmc/articles/PMC8620049/ /pubmed/34829495 http://dx.doi.org/10.3390/diagnostics11112149 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Minokawa, Yoko Sawada, Yu Nakamura, Motonobu The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers |
title | The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers |
title_full | The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers |
title_fullStr | The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers |
title_full_unstemmed | The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers |
title_short | The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers |
title_sort | influences of omega-3 polyunsaturated fatty acids on the development of skin cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620049/ https://www.ncbi.nlm.nih.gov/pubmed/34829495 http://dx.doi.org/10.3390/diagnostics11112149 |
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