New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors

A series of 3-benzylideneindolin-2-one compounds was designed and synthesized based on combretastatin A-4 and compound IC261, a dual casein kinase (CK1)/tubulin polymerization inhibitor, taking into consideration the pharmacophore required for EGFR-tyrosine kinase inhibition. The new molecular entit...

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Detalles Bibliográficos
Autores principales: Fareed, Momen R., Shoman, Mai E., Hamed, Mohammed I. A., Badr, Mohamed, Bogari, Hanin A., Elhady, Sameh S., Ibrahim, Tarek S., Abuo-Rahma, Gamal El-Din A., Ali, Taha F. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620390/
https://www.ncbi.nlm.nih.gov/pubmed/34832895
http://dx.doi.org/10.3390/ph14111114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620390/
https://www.ncbi.nlm.nih.gov/pubmed/34832895
http://dx.doi.org/10.3390/ph14111114

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