Formulation and Development of Oral Fast-Dissolving Films Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers

Paroxetine (PX) is the most potent serotonin reuptake inhibitor utilized in depression and anxiety treatment. It has drawbacks, such as having a very bitter taste, low water solubility, and undergoing extensive first pass metabolism, leading to poor oral bioavailability (<50%). This work aimed to...

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Detalles Bibliográficos
Autores principales: Elshafeey, Ahmed Hassen, El-Dahmy, Rania Moataz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620498/
https://www.ncbi.nlm.nih.gov/pubmed/34834284
http://dx.doi.org/10.3390/pharmaceutics13111869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620498/
https://www.ncbi.nlm.nih.gov/pubmed/34834284
http://dx.doi.org/10.3390/pharmaceutics13111869

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