Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents

A mild and versatile method based on Cu-catalyzed [2+3] cycloaddition (Huisgen-Meldal-Sharpless reaction) was developed to tether 3,3’-((4-(prop-2-yn-1-yloxy)phenyl)methylene)bis(4-hydroxyquinolin-2(1H)-ones) with 4-azido-2-quinolones in good yields. This methodology allowed attaching three quinolon...

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Detalles Bibliográficos
Autores principales: El-Sheref, Essmat M., Elbastawesy, Mohammed A. I., Brown, Alan B., Shawky, Ahmed M., Gomaa, Hesham A. M., Bräse, Stefan, Youssif, Bahaa G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620910/
https://www.ncbi.nlm.nih.gov/pubmed/34833890
http://dx.doi.org/10.3390/molecules26226798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620910/
https://www.ncbi.nlm.nih.gov/pubmed/34833890
http://dx.doi.org/10.3390/molecules26226798

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