Glycan Profile Analysis of Engineered Trastuzumab with Rationally Added Glycosylation Sequons Presents Significantly Increased Glycan Complexity

Protein aggregation constitutes a recurring complication in the manufacture and clinical use of therapeutic monoclonal antibodies (mAb) and mAb derivatives. Antibody aggregates can reduce production yield, cause immunogenic reactions, decrease the shelf-life of the pharmaceutical product and impair...

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Detalles Bibliográficos
Autores principales: Cruz, Esteban, Sifniotis, Vicki, Sumer-Bayraktar, Zeynep, Reslan, Mouhamad, Wilkinson-White, Lorna, Cordwell, Stuart, Kayser, Veysel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620955/
https://www.ncbi.nlm.nih.gov/pubmed/34834161
http://dx.doi.org/10.3390/pharmaceutics13111747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620955/
https://www.ncbi.nlm.nih.gov/pubmed/34834161
http://dx.doi.org/10.3390/pharmaceutics13111747

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