Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones

The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm. XPO1 is considered a relevant target in different human diseases, particularly in hematological malignancies, tumor resistance, i...

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Detalles Bibliográficos
Autores principales: Gargantilla, Marta, López-Fernández, José, Camarasa, Maria-Jose, Persoons, Leentje, Daelemans, Dirk, Priego, Eva-Maria, Pérez-Pérez, María-Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621101/
https://www.ncbi.nlm.nih.gov/pubmed/34832913
http://dx.doi.org/10.3390/ph14111131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621101/
https://www.ncbi.nlm.nih.gov/pubmed/34832913
http://dx.doi.org/10.3390/ph14111131

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