Cargando…

Multiscale Modeling of Amyloid Fibrils Formed by Aggregating Peptides Derived from the Amyloidogenic Fragment of the A-Chain of Insulin

Computational prediction of molecular structures of amyloid fibrils remains an exceedingly challenging task. In this work, we propose a multi-scale modeling procedure for the structure prediction of amyloid fibrils formed by the association of ACC(1-13) aggregation-prone peptides derived from the N-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koliński, Michał, Dec, Robert, Dzwolak, Wojciech
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621111/ https://www.ncbi.nlm.nih.gov/pubmed/34830214 http://dx.doi.org/10.3390/ijms222212325

Ejemplares similares

Extremely Amyloidogenic Single-Chain Analogues of Insulin’s H-Fragment: Structural Adaptability of an Amyloid Stretch
por: Dec, Robert, et al.
Publicado: (2020)

Self-Assembly of Insulin-Derived Chimeric Peptides into Two-Component Amyloid Fibrils: The Role of Coulombic Interactions
por: Fortunka, Mateusz, et al.
Publicado: (2023)

Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils
por: Nizynski, Bartosz, et al.
Publicado: (2018)

The emergence of superstructural order in insulin amyloid fibrils upon multiple rounds of self-seeding
por: Surmacz-Chwedoruk, Weronika, et al.
Publicado: (2016)

Structural characterisation of amyloid-like fibrils formed by an amyloidogenic peptide segment of β-lactoglobulin
por: Gowda, Vasantha, et al.
Publicado: (2021)

Virtual Quasi-2D Intermediates as Building Blocks for Plausible Structural Models of Amyloid Fibrils from Proteins with Complex Topologies: A Case Study of Insulin
por: Puławski, Wojciech, et al.
Publicado: (2022)

Aggregation of an Amyloidogenic Peptide on Gold Surfaces
por: Cheung, David L.
Publicado: (2023)

Mellitate: A multivalent anion with extreme charge density causes rapid aggregation and misfolding of wild type lysozyme at neutral pH
por: Ścibisz, Grzegorz, et al.
Publicado: (2017)

On the Heat Stability of Amyloid-Based Biological Activity: Insights from Thermal Degradation of Insulin Fibrils
por: Surmacz-Chwedoruk, Weronika, et al.
Publicado: (2014)

Effects of Intramolecular Distance between Amyloidogenic Domains on Amyloid Aggregation
por: Ko, Ahra, et al.
Publicado: (2012)

Hsp70 and Antifibrillogenic Peptides Promote Degradation and Inhibit Intracellular Aggregation of Amyloidogenic Light Chains
por: Dul, Jeanne L., et al.
Publicado: (2001)

Aggregation of Amyloidogenic Peptide Uperin—Molecular Dynamics Simulations
por: Ermakova, Elena, et al.
Publicado: (2023)

Distinct position-specific sequence features of hexa-peptides that form amyloid-fibrils: application to discriminate between amyloid fibril and amorphous β-aggregate forming peptide sequences
por: Thangakani, A Mary, et al.
Publicado: (2013)

Mechanism of Amyloid Gel Formation by Several Short Amyloidogenic Peptides
por: Galzitskaya, Oxana V., et al.
Publicado: (2021)

Dimensionality of Carbon Nanomaterials Determines the Binding and Dynamics of Amyloidogenic Peptides: Multiscale Theoretical Simulations
por: Todorova, Nevena, et al.
Publicado: (2013)

Lysozyme Fibrils Alter the Mechanism of Insulin Amyloid Aggregation
por: Ziaunys, Mantas, et al.
Publicado: (2021)

A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35
por: Nasica-Labouze, Jessica, et al.
Publicado: (2011)

Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
por: Hora, Manuel, et al.
Publicado: (2017)

Prediction of fibril formation by early-stage amyloid peptide aggregation
por: Hu, Jiaojiao, et al.
Publicado: (2020)

Competition between crystal and fibril formation in molecular mutations of amyloidogenic peptides
por: Reynolds, Nicholas P., et al.
Publicado: (2017)

Heparin Induces Harmless Fibril Formation in Amyloidogenic W7FW14F Apomyoglobin and Amyloid Aggregation in Wild-Type Protein In Vitro
por: Vilasi, Silvia, et al.
Publicado: (2011)

Modulation of Amyloidogenic Peptide Aggregation by Photoactivatable CO-Releasing Ruthenium(II) Complexes
por: Florio, Daniele, et al.
Publicado: (2020)

Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins
por: Ulamec, Sabine M., et al.
Publicado: (2020)

Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils—A metric for predicting amyloid propensity
por: Martin, Emily B., et al.
Publicado: (2017)

The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation
por: Corti, Roberta, et al.
Publicado: (2020)

Effect of Differences in the Primary Structure of the A-Chain on the Aggregation of Insulin Fragments
por: Nakka, Paul P., et al.
Publicado: (2018)

The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties
por: Olari, Lia-Raluca, et al.
Publicado: (2023)

Structural Similarities and Differences between Amyloidogenic and Non-Amyloidogenic Islet Amyloid Polypeptide (IAPP) Sequences and Implications for the Dual Physiological and Pathological Activities of These Peptides
por: Wu, Chun, et al.
Publicado: (2013)

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity
por: Spitzer, Philipp, et al.
Publicado: (2016)

IgG Conformer's Binding to Amyloidogenic Aggregates
por: Phay, Monichan, et al.
Publicado: (2015)

Amyloid Fibrils Formed by Short Prion-Inspired Peptides Are Metalloenzymes
por: Navarro, Susanna, et al.
Publicado: (2023)

Integrative modeling of diverse protein-peptide systems using CABS-dock
por: Puławski, Wojciech, et al.
Publicado: (2023)

Fibril Fragmentation Enhances Amyloid Cytotoxicity
por: Xue, Wei-Feng, et al.
Publicado: (2009)

α-Helical Structures Drive Early Stages of Self-Assembly of Amyloidogenic Amyloid Polypeptide Aggregate Formation in Membranes
por: Pannuzzo, Martina, et al.
Publicado: (2013)

Author Correction: Competition between crystal and fibril formation in molecular mutations of amyloidogenic peptides
por: Reynolds, Nicholas P., et al.
Publicado: (2017)

Heparan sulfates facilitate harmless amyloidogenic fibril formation interacting with elastin-like peptides
por: Boraldi, Federica, et al.
Publicado: (2018)

Near-Wall Aggregation of Amyloidogenic Aβ 1-40 Peptide: Direct Observation by the FRET
por: Katina, Natalia, et al.
Publicado: (2021)

Assembly Mechanism for Aggregation of Amyloid Fibrils
por: Zhang, Lingyun
Publicado: (2018)

Self-Replication of Prion Protein Fragment 89-230 Amyloid Fibrils Accelerated by Prion Protein Fragment 107-143 Aggregates
por: Sneideris, Tomas, et al.
Publicado: (2020)

Unveiling the Effects of Copper Ions in the Aggregation of Amyloidogenic Proteins
por: Oliveri, Valentina
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lq7ss96jfmo6anbantekdrhba2