Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

The anti-apoptotic myeloid cell leukemia 1 (MCL1) protein belongs to the pro-survival BCL2 family and is frequently amplified or elevated in human cancers. MCL1 is highly unstable, with its stability being regulated by phosphorylation and ubiquitination. Here, we identify acetylation as another crit...

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Detalles Bibliográficos
Autores principales: Shimizu, Kouhei, Gi, Min, Suzuki, Shugo, North, Brian J., Watahiki, Asami, Fukumoto, Satoshi, Asara, John M., Tokunaga, Fuminori, Wei, Wenyi, Inuzuka, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621139/
https://www.ncbi.nlm.nih.gov/pubmed/34758305
http://dx.doi.org/10.1016/j.celrep.2021.109988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621139/
https://www.ncbi.nlm.nih.gov/pubmed/34758305
http://dx.doi.org/10.1016/j.celrep.2021.109988

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