New Bioactive Fused Triazolothiadiazoles as Bcl-2-Targeted Anticancer Agents

A series of 3-(6-substituted phenyl-[1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazol-3-yl)-1H-indoles (5a–l) were designed, synthesized and evaluated for anti-apoptotic Bcl-2-inhibitory activity. Synthesis of the target compounds was readily accomplished through a reaction of acyl hydrazide (1) with carbo...

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Detalles Bibliográficos
Autores principales: Hamdy, Rania, Jones, Arwyn T., El-Sadek, Mohamed, Hamoda, Alshaimaa M., Shakartalla, Sarra B., AL Shareef, Zainab M., Soliman, Sameh S. M., Westwell, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621373/
https://www.ncbi.nlm.nih.gov/pubmed/34830153
http://dx.doi.org/10.3390/ijms222212272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621373/
https://www.ncbi.nlm.nih.gov/pubmed/34830153
http://dx.doi.org/10.3390/ijms222212272

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