Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury

Increased expression and activity of the Ca(2+) channel transient receptor potential channel 6 (TRPC6) is associated with focal segmental glomerulosclerosis, but therapeutic strategies to target TRPC6 are currently lacking. Nitric oxide (NO) is crucial for normal glomerular function and plays a prot...

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Detalles Bibliográficos
Autores principales: ‘t Hart, Daan, Li, Jinhua, van der Vlag, Johan, Nijenhuis, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621407/
https://www.ncbi.nlm.nih.gov/pubmed/34830371
http://dx.doi.org/10.3390/ijms222212485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621407/
https://www.ncbi.nlm.nih.gov/pubmed/34830371
http://dx.doi.org/10.3390/ijms222212485

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