New Antifungal Compound: Impact of Cosolvency, Micellization and Complexation on Solubility and Permeability Processes

Poor solubility of new antifungal of 1,2,4-triazole class (S-119)—a structural analogue of fluconazole in aqueous media was estimated. The solubility improvement using different excipients: biopolymers (PEGs, PVP), surfactants (Brij S20, pluronic F-127) and cyclodextrins (α-CD, β-CD, 2-HP-β-CD, 6-O-...

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Detalles Bibliográficos
Autores principales: Volkova, Tatyana V., Simonova, Olga R., Perlovich, German L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621413/
https://www.ncbi.nlm.nih.gov/pubmed/34834280
http://dx.doi.org/10.3390/pharmaceutics13111865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621413/
https://www.ncbi.nlm.nih.gov/pubmed/34834280
http://dx.doi.org/10.3390/pharmaceutics13111865

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