Cargando…

New Investigations with Lupane Type A-Ring Azepane Triterpenoids for Antimycobacterial Drug Candidate Design

Twenty lupane type A-ring azepano-triterpenoids were synthesized from betulin and its related derivatives and their antitubercular activity against Mycobacterium tuberculosis, mono-resistant MTB strains, and nontuberculous strains Mycobacterium abscessus and Mycobacterium avium were investigated in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kazakova, Oxana, Racoviceanu, Roxana, Petrova, Anastasiya, Mioc, Marius, Militaru, Adrian, Udrescu, Lucreția, Udrescu, Mihai, Voicu, Adrian, Cummings, Jason, Robertson, Gregory, Ordway, Diane J., Slayden, Richard A., Șoica, Codruța
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621456/ https://www.ncbi.nlm.nih.gov/pubmed/34830423 http://dx.doi.org/10.3390/ijms222212542

Ejemplares similares

3-Pyridinylidene Derivatives of Chemically Modified Lupane and Ursane Triterpenes as Promising Anticancer Agents by Targeting Apoptosis
por: Kazakova, Oxana, et al.
Publicado: (2021)

Biocatalysis in the Chemistry of Lupane Triterpenoids
por: Bachořík, Jan, et al.
Publicado: (2021)

Evaluation of Cytotoxicity and α-Glucosidase Inhibitory Activity of Amide and Polyamino-Derivatives of Lupane Triterpenoids
por: Kazakova, Oxana B., et al.
Publicado: (2020)

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)
por: Mioc, Marius, et al.
Publicado: (2022)

Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids
por: Smirnova, Irina, et al.
Publicado: (2022)

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents
por: Şoica, Codruţa, et al.
Publicado: (2021)

Novel Synthesized N-Ethyl-Piperazinyl-Amides of C2-Substituted Oleanonic and Ursonic Acids Exhibit Cytotoxic Effects through Apoptotic Cell Death Regulation
por: Kazakova, Oxana, et al.
Publicado: (2021)

The curse and blessing of abundance—the evolution of drug interaction databases and their impact on drug network analysis
por: Udrescu, Mihai, et al.
Publicado: (2023)

The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges
por: Milan, Andreea, et al.
Publicado: (2022)

Network science meets respiratory medicine for OSAS phenotyping and severity prediction
por: Mihaicuta, Stefan, et al.
Publicado: (2017)

Gender Phenotyping of Patients with Obstructive Sleep Apnea Syndrome Using a Network Science Approach
por: Topîrceanu, Alexandru, et al.
Publicado: (2020)

Drug Repurposing Using Modularity Clustering in Drug-Drug Similarity Networks Based on Drug–Gene Interactions
por: Groza, Vlad, et al.
Publicado: (2021)

The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents
por: Prodea, Alexandra, et al.
Publicado: (2022)

Newly Synthesized CoFe(2−x)Dy(x)O(4) (x = 0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells
por: Rotunjanu, Slaviţa, et al.
Publicado: (2023)

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
por: Ghiulai, Roxana, et al.
Publicado: (2020)

Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine
por: Mihaicuta, Stefan, et al.
Publicado: (2021)

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
por: Mioc, Marius, et al.
Publicado: (2022)

The Antimelanoma Biological Assessment of Triterpenic Acid Functionalized Gold Nanoparticles
por: Mioc, Marius, et al.
Publicado: (2023)

Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
por: Han, Dong, et al.
Publicado: (2022)

Semisynthetic Derivatives of Pentacyclic Triterpenes Bearing Heterocyclic Moieties with Therapeutic Potential
por: Nistor, Gabriela, et al.
Publicado: (2022)

The C30-Modulation of Betulinic Acid Using 1,2,4-Triazole: A Promising Strategy for Increasing Its Antimelanoma Cytotoxic Potential
por: Nistor, Gabriela, et al.
Publicado: (2022)

Decoration of A-Ring of a Lupane-Type Triterpenoid with Different Oxygen and Nitrogen Heterocycles
por: Sousa, Joana L. C., et al.
Publicado: (2022)

Clustering drug-drug interaction networks with energy model layouts: community analysis and drug repurposing
por: Udrescu, Lucreţia, et al.
Publicado: (2016)

SAS score: Targeting high-specificity for efficient population-wide monitoring of obstructive sleep apnea
por: Topîrceanu, Alexandru, et al.
Publicado: (2018)

Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents
por: Mioc, Marius, et al.
Publicado: (2022)

The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles: A Mechanistic In Vitro Approach
por: Ghiulai, Roxana, et al.
Publicado: (2022)

Fe(3)O(4)-PAA–(HP-γ-CDs) Biocompatible Ferrimagnetic Nanoparticles for Increasing the Efficacy in Superparamagnetic Hyperthermia
por: Caizer, Costica, et al.
Publicado: (2022)

Antileishmanial Activity of Semisynthetic Lupane Triterpenoids Betulin and Betulinic Acid Derivatives: Synergistic Effects with Miltefosine
por: Sousa, Maria C., et al.
Publicado: (2014)

Cardiac Protection of a Novel Lupane-Type Triterpenoid from Injuries Induced by Hypoxia–Reperfusion
por: Guo, Beibei, et al.
Publicado: (2022)

Uncovering New Drug Properties in Target-Based Drug–Drug Similarity Networks
por: Udrescu, Lucreţia, et al.
Publicado: (2020)

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity
por: Racoviceanu, Roxana, et al.
Publicado: (2020)

Fractional Dynamics Foster Deep Learning of COPD Stage Prediction (Adv. Sci. 12/2023)
por: Yin, Chenzhong, et al.
Publicado: (2023)

Fractional Dynamics Foster Deep Learning of COPD Stage Prediction
por: Yin, Chenzhong, et al.
Publicado: (2023)

Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity
por: Nicolov, Mirela, et al.
Publicado: (2019)

3-Chloroazepan-2-one
por: Wang, De-Cai, et al.
Publicado: (2010)

Three new C-27-carboxylated-lupane-triterpenoid derivatives from Potentilla discolor Bunge and their in vitro antitumor activities
por: Zhang, Jing, et al.
Publicado: (2017)

Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids
por: Kirstgen, Michael, et al.
Publicado: (2020)

Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry
por: Ghiulai, Roxana, et al.
Publicado: (2022)

β-Turn Induction by a Diastereopure Azepane-Derived Quaternary Amino Acid
por: Núñez-Villanueva, Diego, et al.
Publicado: (2023)

1-Benzoyl-3-chloroazepan-2-one
por: Liu, Hua-Quan, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_58u340sorkj12b69u9d2dl6sel