Empagliflozin Ameliorates Free Fatty Acid Induced-Lipotoxicity in Renal Proximal Tubular Cells via the PPARγ/CD36 Pathway in Obese Mice

High serum levels of free fatty acids (FFAs) could contribute to obesity-induced nephropathy. CD36, a class B scavenger receptor, is a major receptor mediating FFA uptake in renal proximal tubular cells. Empagliflozin, a new anti-diabetic agent, is a specific inhibitor of sodium-glucose co-transport...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Chiang-Chi, Chou, Chia-An, Chen, Wei-Yu, Yang, Jenq-Lin, Lee, Wen-Chin, Chen, Jin-Bor, Lee, Chien-Te, Li, Lung-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621539/
https://www.ncbi.nlm.nih.gov/pubmed/34830289
http://dx.doi.org/10.3390/ijms222212408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621539/
https://www.ncbi.nlm.nih.gov/pubmed/34830289
http://dx.doi.org/10.3390/ijms222212408

Ejemplares similares