Cargando…

Empagliflozin Ameliorates Free Fatty Acid Induced-Lipotoxicity in Renal Proximal Tubular Cells via the PPARγ/CD36 Pathway in Obese Mice

High serum levels of free fatty acids (FFAs) could contribute to obesity-induced nephropathy. CD36, a class B scavenger receptor, is a major receptor mediating FFA uptake in renal proximal tubular cells. Empagliflozin, a new anti-diabetic agent, is a specific inhibitor of sodium-glucose co-transport...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Chiang-Chi, Chou, Chia-An, Chen, Wei-Yu, Yang, Jenq-Lin, Lee, Wen-Chin, Chen, Jin-Bor, Lee, Chien-Te, Li, Lung-Chih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621539/ https://www.ncbi.nlm.nih.gov/pubmed/34830289 http://dx.doi.org/10.3390/ijms222212408

Ejemplares similares

Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease
por: Wang, Hua, et al.
Publicado: (2021)

Empagliflozin reduces podocyte lipotoxicity in experimental Alport syndrome
por: Ge, Mengyuan, et al.
Publicado: (2023)

Empagliflozin Inhibits IL-1β-Mediated Inflammatory Response in Human Proximal Tubular Cells
por: Pirklbauer, Markus, et al.
Publicado: (2021)

Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice
por: Zhao, Zhuohui, et al.
Publicado: (2022)

The CD36-PPARγ Pathway in Metabolic Disorders
por: Maréchal, Loïze, et al.
Publicado: (2018)

Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells
por: Iwai, Tamaki, et al.
Publicado: (2016)

Glucagon‐like peptide‐1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARα pathway
por: Wu, Lujin, et al.
Publicado: (2018)

Empagliflozin does not reverse lipotoxicity-induced impairment in human myeloid angiogenic cell bioenergetics
por: Cinquegrani, Gloria, et al.
Publicado: (2022)

Relationship between PPARα activation and NO on proximal tubular Na(+ )transport in the rat
por: Newaz, Mohammad A, et al.
Publicado: (2004)

SUMOylation of PPARγ by Rosiglitazone Prevents LPS-Induced NCoR Degradation Mediating Down Regulation of Chemokines Expression in Renal Proximal Tubular Cells
por: Lu, Ying, et al.
Publicado: (2013)

Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis
por: Zheng, Qian-Wen, et al.
Publicado: (2021)

Empagliflozin ameliorates symptoms of diabetes and renal tubular dysfunction in a rat model of diabetes with enlarged kidney (DEK)
por: Domon, Ayaka, et al.
Publicado: (2021)

New insights into the role of empagliflozin on diabetic renal tubular lipid accumulation
por: Sun, Hong, et al.
Publicado: (2022)

No Cytotoxic and Inflammatory Effects of Empagliflozin and Dapagliflozin on Primary Renal Proximal Tubular Epithelial Cells under Diabetic Conditions In Vitro
por: Baer, Patrick C., et al.
Publicado: (2020)

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
por: Rada, Patricia, et al.
Publicado: (2020)

MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice
por: Wang, Xu, et al.
Publicado: (2017)

Bean Leaves Ameliorate Lipotoxicity in Fatty Liver Disease
por: Becerril-Campos, Adriana Araceli, et al.
Publicado: (2023)

P-Glycoprotein Induction Ameliorates Colistin Induced Nephrotoxicity in Cultured Human Proximal Tubular Cells
por: Lee, Sun-hyo, et al.
Publicado: (2015)

Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha
por: Ndibalema, Angelamellisy Revelian, et al.
Publicado: (2020)

Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells
por: Pirklbauer, Markus, et al.
Publicado: (2020)

Fingolimod treatment modulates PPARγ and CD36 gene expression in women with multiple sclerosis
por: Ferret-Sena, Véronique, et al.
Publicado: (2022)

Role of CD36 in Palmitic Acid Lipotoxicity in Neuro-2a Neuroblastoma Cells
por: Urso, C. J., et al.
Publicado: (2021)

β-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice
por: Jeong, Moon Hee, et al.
Publicado: (2014)

Pioglitazone modulates immune activation and ameliorates inflammation induced by injured renal tubular epithelial cells via PPARγ/miRNA‑124/STAT3 signaling
por: El Gazzar, Walaa Bayoumie, et al.
Publicado: (2022)

Aronia melanocarpa Extract Ameliorates Hepatic Lipid Metabolism through PPARγ2 Downregulation
por: Park, Chung-Hwa, et al.
Publicado: (2017)

Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway
por: Tian, Xue, et al.
Publicado: (2022)

Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ
por: Liu, Jinhong, et al.
Publicado: (2020)

PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism
por: Medina-Gomez, Gema, et al.
Publicado: (2007)

Niacin exacerbates β cell lipotoxicity in diet-induced obesity mice through upregulation of GPR109A and PPARγ2: Inhibition by incretin drugs
por: Zhang, Xiaojing, et al.
Publicado: (2022)

Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis
por: Yu, Jung Hwan, et al.
Publicado: (2016)

Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids
por: Urso, C.J., et al.
Publicado: (2021)

Protopanaxadiol ameliorates palmitate-induced lipotoxicity and pancreatic β-cell dysfunction in INS-1 cells
por: Lee, Dahae, et al.
Publicado: (2023)

PEGylated Curcumin Derivative Attenuates Hepatic Steatosis via CREB/PPAR-γ/CD36 Pathway
por: Liu, Yu, et al.
Publicado: (2017)

Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPARγ pathway
por: Ahn, Ji-Su, et al.
Publicado: (2021)

Targeting bile acids and lipotoxicity for NASH treatment
por: Chiang, John Y. L.
Publicado: (2017)

Kidney Injury Molecule-1 Is Upregulated in Renal Lipotoxicity and Mediates Palmitate-Induced Tubular Cell Injury and Inflammatory Response
por: Zhao, Xueying, et al.
Publicado: (2019)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Proximal Tubular Hypertrophy and Enlarged Glomerular and Proximal Tubular Urinary Space in Obese Subjects with Proteinuria
por: Tobar, Ana, et al.
Publicado: (2013)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

PPARγ Agonist and Angiotensin II Receptor Antagonist Ameliorate Renal Tubulointerstitial Fibrosis
por: Han, Jee-Young, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_2bufrgapopajfaa2b3m221ru4g