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A Unique Topoisomerase II Inhibitor with Dose-Affected Anticancer Mechanisms and Less Cardiotoxicity

Type II DNA topoisomerase (topo II) is an essential nuclear enzyme and a well-validated anticancer drug target. Previously, we have carried out several rounds of structural optimizations on our in-house topo II inhibitor E17, which was shown to have superior anticancer activity and less risk of mult...

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Detalles Bibliográficos
Autores principales: Li, Zhi-Ying, Xu, Guang-Sen, Li, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621772/
https://www.ncbi.nlm.nih.gov/pubmed/34831359
http://dx.doi.org/10.3390/cells10113138