Cargando…

IL-10 mRNA Engineered MSCs Demonstrate Enhanced Anti-Inflammation in an Acute GvHD Model

Mesenchymal stem cells (MSCs) are used in various studies to induce immunomodulatory effects in clinical conditions associated with immune dysregulation such as graft versus host disease (GvHD). However, most of these clinical trials failed to go beyond early phase 2 studies because of limited effic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Cuiping, Delawary, Mina, Huang, Peng, Korchak, Jennifer A., Suda, Koji, Zubair, Abba C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621791/ https://www.ncbi.nlm.nih.gov/pubmed/34831324 http://dx.doi.org/10.3390/cells10113101

Ejemplares similares

Inflammasome effects in GvHD
por: Koehn, Brent H., et al.
Publicado: (2015)

Editorial: Interferons and GvHD
por: Kim, Boram, et al.
Publicado: (2022)

Antibody- and aptamer-strategies for GvHD prevention
por: Oelkrug, Christopher, et al.
Publicado: (2015)

Established and Emerging Treatments of Skin GvHD
por: Link-Rachner, Cornelia S., et al.
Publicado: (2022)

Chronic GvHD NIH Consensus Project Biology Task Force: evolving path to personalized treatment of chronic GvHD
por: Buxbaum, Nataliya P., et al.
Publicado: (2022)

The Role of Bacteria and Pattern Recognition Receptors in GvHD
por: Holler, E., et al.
Publicado: (2010)

Effects of immune system cells in GvHD and corresponding therapeutic strategies
por: Tavaf, Maryam Jadid, et al.
Publicado: (2023)

Pathophysiology of GvHD and Other HSCT-Related Major Complications
por: Ghimire, Sakhila, et al.
Publicado: (2017)

New insights about immune populations in gastrointestinal GvHD
por: Hayase, Eiko, et al.
Publicado: (2023)

Immunometabolic Therapeutic Targets of Graft-versus-Host Disease (GvHD)
por: Mhandire, Kudakwashe, et al.
Publicado: (2021)

Targeting IFNGR/IL6R or downstream JAK1/JAK2 to control GvHD
por: Ashami, Kidist, et al.
Publicado: (2018)

Bone Marrow GvHD after Allogeneic Hematopoietic Stem Cell Transplantation
por: Szyska, Martin, et al.
Publicado: (2016)

CrkL is required for donor T cell migration to GvHD target organs
por: Roy, Nathan H., et al.
Publicado: (2020)

Antigen-Specific Priming is Dispensable in Depletion of Apoptosis-Sensitive T Cells for GvHD Prophylaxis
por: Yarkoni, Shai, et al.
Publicado: (2014)

Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells
por: Riegel, Christin, et al.
Publicado: (2019)

Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
por: Roberto, Crocchiolo, et al.
Publicado: (2021)

Extracorporeal photopheresis as an immunomodulatory treatment modality for chronic GvHD and the importance of emerging biomarkers
por: Bojanic, Ines, et al.
Publicado: (2023)

Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers
por: Li, Yan-Ruide, et al.
Publicado: (2022)

The Relationship between STR-PCR Chimerism Analysis and Chronic GvHD Following Hematopoietic Stem Cell Transplantation
por: Mousavi, Seyed Asadollah, et al.
Publicado: (2017)

Correction to: Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
por: Crocchiolo, Roberto, et al.
Publicado: (2021)

Spontaneous xenogeneic GvHD in Wilms' tumor Patient‐Derived xenograft models and potential solutions
por: Monzavi, Seyed Mostafa, et al.
Publicado: (2022)

Accumulation of T-cell-suppressive PD-L1(high) extracellular vesicles is associated with GvHD and might impact GvL efficacy
por: Baur, Rebecca, et al.
Publicado: (2023)

The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview
por: Boieri, Margherita, et al.
Publicado: (2016)

FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition
por: Ryu, Jaeyoon, et al.
Publicado: (2020)

Interleukin-6 as Biomarker for Acute GvHD and Survival After Allogeneic Transplant With Post-transplant Cyclophosphamide
por: Greco, Raffaella, et al.
Publicado: (2019)

Third-party type 2 innate lymphoid cells prevent and treat GI tract GvHD
por: Bruce, Danny W., et al.
Publicado: (2021)

Tacrolimus initial steady state level in post-transplant cyclophosphamide based GvHD prophylaxis regimens
por: Yao, Janny M., et al.
Publicado: (2022)

Effective Extracorporeal Photopheresis of Patients with Transplantation Induced Acute Intestinal GvHD and Bronchiolitis Obliterans Syndrome
por: Reschke, Robin, et al.
Publicado: (2022)

Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells
por: Shaikh, Haroon, et al.
Publicado: (2022)

IL‐12/15/18‐preactivated NK cells suppress GvHD in a mouse model of mismatched hematopoietic cell transplantation
por: Hüber, Christian M., et al.
Publicado: (2015)

Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases
por: Wernicke, Caroline M, et al.
Publicado: (2011)

Pharmacologic Blockade of JAK1/JAK2 Reduces GvHD and Preserves the Graft-Versus-Leukemia Effect
por: Choi, Jaebok, et al.
Publicado: (2014)

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion
por: Chopra, Martin, et al.
Publicado: (2016)

Evidence for CD19B–CD8T cell interactions in blood and tissues from patients with GvHD
por: Deola, S, et al.
Publicado: (2017)

Treatment of chronic GvHD with mesenchymal stromal cells induces durable responses: A phase II study
por: Boberg, Erik, et al.
Publicado: (2020)

(18)F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD)
por: Roll, Wolfgang, et al.
Publicado: (2021)

GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics
por: Ghimire, Sakhila, et al.
Publicado: (2021)

Burden and Needs of Patients with Severe GvHD from the Supportive and Palliative Care Perspective—A Literature Review
por: Wenzel, Freya, et al.
Publicado: (2021)

Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD
por: Landwehr-Kenzel, Sybille, et al.
Publicado: (2021)

ICOS immunoPET enables visualization of activated T cells and early diagnosis of murine acute gastrointestinal GvHD
por: Xiao, Zunyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k23ojq05k65gkaf0p2gn2esruc