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Fate of Tableted Freeze-Dried siRNA Lipoplexes in Gastrointestinal Environment

The incorporation of siRNA into nanocarriers is mandatory to facilitate its intracellular delivery, as siRNA itself cannot enter cells. However, the incorporation of these nanocarriers into oral, solid dosage forms and their fate in the gastrointestinal environment is yet to be explored. In the pres...

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Detalles Bibliográficos
Autores principales: Rehman, Asad Ur, Busignies, Virginie, Coelho Silva Ribeiro, Marcela, Almeida Lage, Nayara, Tchoreloff, Pierre, Escriou, Virginie, Charrueau, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622262/
https://www.ncbi.nlm.nih.gov/pubmed/34834222
http://dx.doi.org/10.3390/pharmaceutics13111807