Molecular Modeling Studies of N-phenylpyrimidine-4-amine Derivatives for Inhibiting FMS-like Tyrosine Kinase-3

Overexpression and frequent mutations in FMS-like tyrosine kinase-3 (FLT3) are considered risk factors for severe acute myeloid leukemia (AML). Hyperactive FLT3 induces premature activation of multiple intracellular signaling pathways, resulting in cell proliferation and anti-apoptosis. We conducted...

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Detalles Bibliográficos
Autores principales: Ghosh, Suparna, Keretsu, Seketoulie, Cho, Seung Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622510/
https://www.ncbi.nlm.nih.gov/pubmed/34830393
http://dx.doi.org/10.3390/ijms222212511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622510/
https://www.ncbi.nlm.nih.gov/pubmed/34830393
http://dx.doi.org/10.3390/ijms222212511

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