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Synthesis, Molecular Docking, and Antimalarial Activity of Hybrid 4-Aminoquinoline-pyrano[2,3-c]pyrazole Derivatives

Widespread resistance of Plasmodium falciparum to current artemisinin-based combination therapies necessitate the discovery of new medicines. Pharmacophoric hybridization has become an alternative for drug resistance that lowers the risk of drug–drug adverse interactions. In this study, we synthesiz...

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Detalles Bibliográficos
Autores principales: Shamsuddin, Mohd Asyraf, Ali, Amatul Hamizah, Zakaria, Nur Hanis, Mohammat, Mohd Fazli, Hamzah, Ahmad Sazali, Shaameri, Zurina, Lam, Kok Wai, Mark-Lee, Wun Fui, Agustar, Hani Kartini, Mohd Abd Razak, Mohd Ridzuan, Latip, Jalifah, Hassan, Nurul Izzaty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622706/
https://www.ncbi.nlm.nih.gov/pubmed/34832956
http://dx.doi.org/10.3390/ph14111174