Absolute Structure Determination and Kv1.5 Ion Channel Inhibition Activities of New Debromoaplysiatoxin Analogues

Potassium channel Kv1.5 has been considered a key target for new treatments of atrial tachyarrhythmias, with few side effects. Four new debromoaplysiatoxin analogues with a 6/6/12 fused ring system were isolated from marine cyanobacterium Lyngbya sp. Their planar structures were elucidated by HRESIM...

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Detalles Bibliográficos
Autores principales: Shen, Sicheng, Wang, Weiping, Chen, Zijun, Zhang, Huihui, Yang, Yuchun, Wang, Xiaoliang, Fu, Peng, Han, Bingnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622842/
https://www.ncbi.nlm.nih.gov/pubmed/34822501
http://dx.doi.org/10.3390/md19110630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622842/
https://www.ncbi.nlm.nih.gov/pubmed/34822501
http://dx.doi.org/10.3390/md19110630

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