Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach

Background: Tacrolimus (Tac) is characterized by large between- and within-patient (IPV) variability in pharmacokinetics and exposure. Aim: This study aimed to assess and validate the effect of Tac IPV and trough concentration-to-dose ratio (C(0)/D) over 6–12 months on reduced estimated glomerular f...

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Detalles Bibliográficos
Autores principales: Stefanović, Nikola, Veličković-Radovanović, Radmila, Danković, Katarina, Pavlović, Ivan, Catić-Đorđević, Aleksandra, Bašić, Jelena, Despotović, Milena, Jevtović-Stoimenov, Tatjana, Mitić, Branka, Cvetković, Tatjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622919/
https://www.ncbi.nlm.nih.gov/pubmed/34834385
http://dx.doi.org/10.3390/pharmaceutics13111970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622919/
https://www.ncbi.nlm.nih.gov/pubmed/34834385
http://dx.doi.org/10.3390/pharmaceutics13111970

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