Clinical Safety and Tolerability of A2NTX, a Novel Low-Molecular-Weight Neurotoxin Derived from Botulinum Neurotoxin Subtype A2, in Comparison with Subtype A1 Toxins

All the botulinum type A neurotoxins available for clinical use are of the A1 subtype. We developed a subtype A2 low-molecular-weight (150 kD (kilo Dalton)) neurotoxin (A2NTX) with less spread and faster entry into the motor nerve terminal than A1 in vitro and in vivo. Preliminary clinical studies s...

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Detalles Bibliográficos
Autores principales: Takeuchi, Toshiaki, Okuno, Tsuyoshi, Miyashiro, Ai, Kohda, Tomoko, Miyamoto, Ryosuke, Izumi, Yuishin, Kozaki, Shunji, Kaji, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623066/
https://www.ncbi.nlm.nih.gov/pubmed/34822610
http://dx.doi.org/10.3390/toxins13110824

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