Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells

Spontaneous AP (action potential) firing of sinoatrial nodal cells (SANC) is critically dependent on protein kinase A (PKA) and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent protein phosphorylation, which are required for the generation of spontaneous, diastolic local Ca(2+) relea...

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Detalles Bibliográficos
Autores principales: Sirenko, Syevda Tagirova, Zahanich, Ihor, Li, Yue, Lukyanenko, Yevgeniya O., Lyashkov, Alexey E., Ziman, Bruce D., Tarasov, Kirill V., Younes, Antoine, Riordon, Daniel R., Tarasova, Yelena S., Yang, Dongmei, Vinogradova, Tatiana M., Maltsev, Victor A., Lakatta, Edward G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623309/
https://www.ncbi.nlm.nih.gov/pubmed/34831329
http://dx.doi.org/10.3390/cells10113106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623309/
https://www.ncbi.nlm.nih.gov/pubmed/34831329
http://dx.doi.org/10.3390/cells10113106

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