Cargando…

Investigation of the Mechanisms of Cytotoxic Activity of 1,3-Disubstituted Thiourea Derivatives

Substituted thiourea derivatives possess confirmed cytotoxic activity towards cancer but also normal cells. To develop new selective antitumor agents, a series of 3-(trifluoromethyl)phenylthiourea analogs were synthesized, and their cytotoxicity was evaluated in vitro against the cell line panel. Co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Strzyga-Łach, Paulina, Chrzanowska, Alicja, Podsadni, Katarzyna, Bielenica, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623398/ https://www.ncbi.nlm.nih.gov/pubmed/34832881 http://dx.doi.org/10.3390/ph14111097

Ejemplares similares

Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies
por: Bielenica, Anna, et al.
Publicado: (2018)

The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells
por: Chrzanowska, Alicja, et al.
Publicado: (2021)

Effect of Hydroxyl Groups Esterification with Fatty Acids on the Cytotoxicity and Antioxidant Activity of Flavones
por: Kubiak-Tomaszewska, Grażyna, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of New Schiff Bases Derived from 4-Amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione
por: Janowska, Sara, et al.
Publicado: (2023)

Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives
por: Drzewiecka-Antonik, Aleksandra, et al.
Publicado: (2022)

Synthesis and Identification of New N,N-Disubstituted Thiourea, and Thiazolidinone Scaffolds Based on Quinolone Moiety as Urease Inhibitor
por: Elshaier, Yaseen A. M. M., et al.
Publicado: (2022)

Synthetic Transition from Thiourea-Based Compounds to Tetrazole Derivatives: Structure and Biological Evaluation of Synthesized New N-(Furan-2-ylmethyl)-1H-tetrazol-5-amine Derivatives
por: Szulczyk, Daniel, et al.
Publicado: (2021)

Tail-approach based design, synthesis, and cytotoxic evaluation of novel disubstituted and trisubstituted 1,3-thiazole benzenesulfonamide derivatives with suggested carbonic anhydrase IX inhibition mechanism
por: Bondock, Samir, et al.
Publicado: (2023)

Synthesis, Cytotoxicity, and Antileishmanial Activity of N,N'-Disubstituted Ethylenediamine and Imidazolidine Derivatives
por: de Carvalho, Gustavo S. G., et al.
Publicado: (2010)

Antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives
por: Khodarahmi, G.A., et al.
Publicado: (2012)

Synthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1,5-Disubstituted Triazole
por: Takasu, Kiyosei, et al.
Publicado: (2010)

Thiourea-Derived Chelating Ligands and Their Organometallic Compounds: Investigations into Their Anticancer Activity
por: Tong, Kelvin K. H., et al.
Publicado: (2020)

Synthesis and Investigation of Anti-Inflammatory Activity of New Thiourea Derivatives of Naproxen
por: Nedeljković, Nikola, et al.
Publicado: (2023)

Cytotoxicity Evaluation of Novel bis(2-aminoethyl)amine Derivatives
por: Szulczyk, Daniel, et al.
Publicado: (2020)

Synthesis of 1,3-cis-disubstituted sterically encumbered imidazolidinone organocatalysts
por: Wallbaum, Jan, et al.
Publicado: (2017)

Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes
por: Song, Shihua, et al.
Publicado: (2019)

Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines
por: Tang, Zilong, et al.
Publicado: (2012)

Cu-Catalyzed Enantioselective Protoboration of 2,3-Disubstituted 1,3-Dienes
por: Liu, Sensheng, et al.
Publicado: (2023)

Biological Activity, Lipophilicity and Cytotoxicity of Novel 3-Acetyl-2,5-disubstituted-1,3,4-oxadiazolines
por: Paruch, Kinga, et al.
Publicado: (2021)

Halide-Mediated Ortho-Deprotonation Reactions Applied to the Synthesis of 1,2- and 1,3-Disubstituted Ferrocene Derivatives
por: Zirakzadeh, Afrooz, et al.
Publicado: (2015)

2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli
por: Korycka-Machała, M., et al.
Publicado: (2022)

Chirality Transfer in Gold(I)‐Catalysed Hydroalkoxylation of 1,3‐Disubstituted Allenes
por: Webster, Stacey, et al.
Publicado: (2016)

Iridium-catalyzed asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines
por: Kim, Alexia N., et al.
Publicado: (2022)

Planar Chiral 1,3-Disubstituted Ferrocenyl Phosphine Gold(I) Catalysts
por: Caniparoli, Ulysse, et al.
Publicado: (2022)

Synthesis, Structure and In Vitro Cytotoxic Activity of Novel Cinchona—Chalcone Hybrids with 1,4-Disubstituted- and 1,5-Disubstituted 1,2,3-Triazole Linkers
por: Jernei, Tamás, et al.
Publicado: (2019)

Tyrosol Derivatives, Bearing 3,5-Disubstituted Isoxazole and 1,4-Disubstituted Triazole, as Potential Antileukemia Agents by Promoting Apoptosis
por: Abdelkafi-Koubaa, Zaineb, et al.
Publicado: (2022)

1,3-Bis(2-methoxyphenyl)thiourea
por: van Rooyen, Jason, et al.
Publicado: (2011)

1,3-Bis(3-methylphenyl)thiourea: triclinic polymorph
por: Shahwar, Durre, et al.
Publicado: (2009)

Novel N,N′-Disubstituted Acylselenoureas as Potential Antioxidant and Cytotoxic Agents
por: Ruberte, Ana Carolina, et al.
Publicado: (2020)

Novel N,N′-Disubstituted Selenoureas as Potential Antioxidant and Cytotoxic Agents
por: Calvo-Martín, Gorka, et al.
Publicado: (2021)

Synthesis of 2,6-disubstituted tetrahydroazulene derivatives
por: Hussain, Zakir, et al.
Publicado: (2012)

Copper Hydride Catalyzed Enantioselective Synthesis of Axially Chiral 1,3-Disubstituted Allenes
por: Bayeh-Romero, Liela, et al.
Publicado: (2019)

A palladium catalyzed asymmetric desymmetrization approach to enantioenriched 1,3-disubstituted isoindolines
por: Dethe, Dattatraya H., et al.
Publicado: (2023)

Anti-Amoebic Properties of Carbonyl Thiourea Derivatives
por: Ibrahim, Maizatul Akma, et al.
Publicado: (2014)

Synthesis and Bioactivity of Pyrazole Acyl Thiourea Derivatives
por: Wu, Jian, et al.
Publicado: (2012)

Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas
por: Sanna, Giuseppina, et al.
Publicado: (2018)

Redox-active tetrathiafulvalene and dithiolene compounds derived from allylic 1,4-diol rearrangement products of disubstituted 1,3-dithiole derivatives
por: Vilela, Filipe, et al.
Publicado: (2010)

1,4-Disubstituted Thiosemicarbazide Derivatives are Potent Inhibitors of Toxoplasma gondii Proliferation
por: Dzitko, Katarzyna, et al.
Publicado: (2014)

Intramolecular Hydrogen Bond Activation: Thiourea-Organocatalyzed Enantioselective 1,3-Dipolar Cycloaddition of Salicylaldehyde-Derived Azomethine Ylides with Nitroalkenes
por: Esteban, Francisco, et al.
Publicado: (2018)

Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives
por: Hassanzadeh, F., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hietukvcl785fhbg2tpgb26lu0