Eletrophilic Chemistry of Tranilast Is Involved in Its Anti-Colitic Activity via Nrf2-HO-1 Pathway Activation

Tranilast (TRL), a synthetic derivative of a tryptophan metabolite, is an anti-allergic drug used to treat bronchial asthma. We investigated how TRL activated the nuclear factor-erythroid 2 p45-related factor 2 (Nrf2)-hemeoxygenase-1 (HO-1) pathway based on the electrophilic chemistry of the drug an...

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Detalles Bibliográficos
Autores principales: Jeong, Seongkeun, Kang, Changyu, Park, Sohee, Ju, Sanghyun, Yoo, Jin-Wook, Yoon, In-Soo, Yun, Hwayoung, Jung, Yunjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623426/
https://www.ncbi.nlm.nih.gov/pubmed/34832874
http://dx.doi.org/10.3390/ph14111092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623426/
https://www.ncbi.nlm.nih.gov/pubmed/34832874
http://dx.doi.org/10.3390/ph14111092

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