Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions

To develop new potent and highly selective MAO-B inhibitors from chalcone-thioethers, eleven chalcones-thioethers were synthesized and their monoamine oxidase (MAO) inhibition, kinetics, reversibility, and cytotoxicity of lead compounds were analyzed. Molecular dynamics were carried out to investiga...

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Detalles Bibliográficos
Autores principales: Mathew, Bijo, Oh, Jong Min, Khames, Ahmed, Abdelgawad, Mohamed A., Rangarajan, T. M., Nath, Lekshmi R., Agoni, Clement, Soliman, Mahmoud E. S., Mathew, Githa Elizabeth, Kim, Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623647/
https://www.ncbi.nlm.nih.gov/pubmed/34832930
http://dx.doi.org/10.3390/ph14111148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623647/
https://www.ncbi.nlm.nih.gov/pubmed/34832930
http://dx.doi.org/10.3390/ph14111148

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