Cyclometalated Iridium(III) Complex–Cationic Peptide Hybrids Trigger Paraptosis in Cancer Cells via an Intracellular Ca(2+) Overload from the Endoplasmic Reticulum and a Decrease in Mitochondrial Membrane Potential

In our previous paper, we reported that amphiphilic Ir complex–peptide hybrids (IPHs) containing basic peptides such as KK(K)GG (K: lysine, G: glycine) (e.g., ASb-2) exhibited potent anticancer activity against Jurkat cells, with the dead cells showing a strong green emission. Our initial mechanisti...

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Detalles Bibliográficos
Autores principales: Balachandran, Chandrasekar, Yokoi, Kenta, Naito, Kana, Haribabu, Jebiti, Tamura, Yuichi, Umezawa, Masakazu, Tsuchiya, Koji, Yoshihara, Toshitada, Tobita, Seiji, Aoki, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623854/
https://www.ncbi.nlm.nih.gov/pubmed/34834120
http://dx.doi.org/10.3390/molecules26227028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623854/
https://www.ncbi.nlm.nih.gov/pubmed/34834120
http://dx.doi.org/10.3390/molecules26227028

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