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Miscibility and Solubility of Caffeine and Theophylline in Hydroxypropyl Methylcellulose

As amorphization may improve the solubility and bioavailability of a drug substance, the aim of this work was to assess to what extent the crystallinity of caffeine (CAF) and theophylline (TF) can be reduced by homogenization with a polymeric excipient. To realize this purpose, the physical mixtures...

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Detalles Bibliográficos
Autores principales:	Leyk, Edyta, Wesolowski, Marek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624303/ https://www.ncbi.nlm.nih.gov/pubmed/34834251 http://dx.doi.org/10.3390/pharmaceutics13111836

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