A Tetravalent Biparatopic Antibody Causes Strong HER2 Internalization and Inhibits Cellular Proliferation

The overexpression of tyrosine kinase HER2 in numerous cancers, connected with fierce signaling and uncontrolled proliferation, makes it a suitable target for immunotherapy. The acquisition of resistance to currently used compounds and the multiplicity of signaling pathways involved prompted researc...

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Detalles Bibliográficos
Autores principales: Benedetti, Filippo, Stadlbauer, Katharina, Stadlmayr, Gerhard, Rüker, Florian, Wozniak-Knopp, Gordana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624325/
https://www.ncbi.nlm.nih.gov/pubmed/34833033
http://dx.doi.org/10.3390/life11111157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624325/
https://www.ncbi.nlm.nih.gov/pubmed/34833033
http://dx.doi.org/10.3390/life11111157

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