Combinatorial Regimen of Carbamazepine and Imipramine Exhibits Synergism against Grandmal Epilepsy in Rats: Inhibition of Pro-Inflammatory Cytokines and PI3K/Akt/mTOR Signaling Pathway

Epilepsy is a neurodegenerative disorder that causes recurring seizures. Thirty-five percent of patients remain refractory, with a higher prevalence of depression. We investigated the anticonvulsant efficacy of carbamazepine (CBZ; 20 and 50 mg/kg), imipramine (IMI; 10 and 20 mg/kg) alone, and as a l...

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Detalles Bibliográficos
Autores principales: Pottoo, Faheem Hyder, Salahuddin, Mohammed, Khan, Firdos Alam, AL Dhamen, Marwa Abdullah, Alsaeed, Walaa Jafar, Gomaa, Mohamed S., Vatte, Chittibabu, Alomary, Mohammad N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624327/
https://www.ncbi.nlm.nih.gov/pubmed/34832986
http://dx.doi.org/10.3390/ph14111204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624327/
https://www.ncbi.nlm.nih.gov/pubmed/34832986
http://dx.doi.org/10.3390/ph14111204

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