Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)

Five novel analogs of 6-(ethyl)(4-isobutoxy-3-isopropylphenyl)amino)nicotinic acid—or NEt-4IB—in addition to seven novel analogs of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) were prepared and evaluated for selective retinoid-X-receptor (RXR) agonism...

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Detalles Bibliográficos
Autores principales: Jurutka, Peter W., di Martino, Orsola, Reshi, Sabeeha, Mallick, Sanchita, Sabir, Zhela L., Staniszewski, Lech J. P., Warda, Ankedo, Maiorella, Emma L., Minasian, Ani, Davidson, Jesse, Ibrahim, Samir J., Raban, San, Haddad, Dena, Khamisi, Madleen, Suban, Stephanie L., Dawson, Bradley J., Candia, Riley, Ziller, Joseph W., Lee, Ming-Yue, Liu, Chang, Liu, Wei, Marshall, Pamela A., Welch, John S., Wagner, Carl E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624485/
https://www.ncbi.nlm.nih.gov/pubmed/34830251
http://dx.doi.org/10.3390/ijms222212371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624485/
https://www.ncbi.nlm.nih.gov/pubmed/34830251
http://dx.doi.org/10.3390/ijms222212371

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