Chiral Aminoalcohols and Squaric Acid Amides as Ligands for Asymmetric Borane Reduction of Ketones: Insight to In Situ Formed Catalytic System by DOSY and Multinuclear NMR Experiments

A series of squaric acid amides (synthesized in 66–99% isolated yields) and a set of chiral aminoalcohols were comparatively studied as ligands in a model reaction of reduction of α-chloroacetophenone with BH(3)•SMe(2). In all cases, the aminoalcohols demonstrated better efficiency (up to 94% ee), w...

Descripción completa

Detalles Bibliográficos
Autores principales: Nikolova, Yana, Dobrikov, Georgi M., Petkova, Zhanina, Shestakova, Pavletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624562/
https://www.ncbi.nlm.nih.gov/pubmed/34833957
http://dx.doi.org/10.3390/molecules26226865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624562/
https://www.ncbi.nlm.nih.gov/pubmed/34833957
http://dx.doi.org/10.3390/molecules26226865

Ejemplares similares