Observations on the Changing Shape of the Ice Mass and the Determination of the Sublimation End Point in Freeze-Drying: An Application for Through-Vial Impedance Spectroscopy (TVIS)

Models for ice sublimation from a freeze-drying vial rely on the assumption of a planar ice interface up to ~25% loss of ice mass (which is difficult to qualify) whereas single-vial determinations of the sublimation endpoint (by temperature sensors) are based on the point when the observed temperatu...

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Detalles Bibliográficos
Autores principales: Pandya, Bhaskar, Smith, Geoff, Ermolina, Irina, Polygalov, Evgeny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624880/
https://www.ncbi.nlm.nih.gov/pubmed/34834255
http://dx.doi.org/10.3390/pharmaceutics13111835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624880/
https://www.ncbi.nlm.nih.gov/pubmed/34834255
http://dx.doi.org/10.3390/pharmaceutics13111835

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