Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic agents; however, the development of multidrug resistance has limited their clinical activity. We report the synthesis and biological properties of a series of novel 3-chloro-β-lactams and 3,3-dichloro-β-lactams (2-...

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Detalles Bibliográficos
Autores principales: Malebari, Azizah M., Wang, Shu, Greene, Thomas F., O’Boyle, Niamh M., Fayne, Darren, Khan, Mohemmed Faraz, Nathwani, Seema M., Twamley, Brendan, McCabe, Thomas, Zisterer, Daniela M., Meegan, Mary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624998/
https://www.ncbi.nlm.nih.gov/pubmed/34832901
http://dx.doi.org/10.3390/ph14111119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624998/
https://www.ncbi.nlm.nih.gov/pubmed/34832901
http://dx.doi.org/10.3390/ph14111119

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