Cargando…

The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation

A growing number of studies indicate that mRNAs and long ncRNAs can affect protein populations by assembling dynamic ribonucleoprotein (RNP) granules. These phase-separated molecular ‘sponges’, stabilized by quinary (transient and weak) interactions, control proteins involved in numerous biological...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lyonnais, Sébastien, Sadiq, S. Kashif, Lorca-Oró, Cristina, Dufau, Laure, Nieto-Marquez, Sara, Escribà, Tuixent, Gabrielli, Natalia, Tan, Xiao, Ouizougun-Oubari, Mohamed, Okoronkwo, Josephine, Reboud-Ravaux, Michèle, Gatell, José Maria, Marquet, Roland, Paillart, Jean-Christophe, Meyerhans, Andreas, Tisné, Carine, Gorelick, Robert J., Mirambeau, Gilles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625067/ https://www.ncbi.nlm.nih.gov/pubmed/34835118 http://dx.doi.org/10.3390/v13112312

Ejemplares similares

RNA remarkably promotes HIV-1 protease fast turnover for NCp15 processing in mild acidic conditions leading to condensation of HIV-1 nucleocapsid
por: Lyonnais, Sebastien, et al.
Publicado: (2013)

HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner
por: Mirambeau, Gilles, et al.
Publicado: (2007)

Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis
por: Mouhand, Assia, et al.
Publicado: (2018)

Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1
por: Mori, Mattia, et al.
Publicado: (2015)

Association study of lipoprotein(a) genetic markers, traditional risk factors, and coronary heart disease in HIV-1-infected patients
por: Egaña-Gorroño, Lander, et al.
Publicado: (2012)

ω-3 supplementation in HIV-1-infected individuals with unsuppressed viral load: cause for caution?
por: Tort, Olivia, et al.
Publicado: (2016)

Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcription
por: Henriet, S., et al.
Publicado: (2007)

Cholesterol efflux responds to viral load and CD4 counts in HIV+ patients and is dampened in HIV exposed
por: Tort, Olivia, et al.
Publicado: (2018)

Structural maturation of the HIV-1 RNA 5’ untranslated region by Pr55(Gag) and its maturation products
por: Gilmer, Orian, et al.
Publicado: (2022)

Differential MicroRNA Expression Profile between Stimulated PBMCs from HIV-1 Infected Elite Controllers and Viremic Progressors
por: Egaña-Gorroño, Lander, et al.
Publicado: (2014)

6(th )International Symposium on Retroviral Nucleocapsid
por: Berkhout, Ben, et al.
Publicado: (2008)

Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain
por: Mouhand, Assia, et al.
Publicado: (2022)

MicroRNA Profile in CD8+ T-Lymphocytes from HIV-Infected Individuals: Relationship with Antiviral Immune Response and Disease Progression
por: Egaña-Gorroño, Lander, et al.
Publicado: (2016)

Requirements for nucleocapsid-mediated regulation of reverse transcription during the late steps of HIV-1 assembly
por: Racine, Pierre-Jean, et al.
Publicado: (2016)

Hijacking of the Ubiquitin/Proteasome Pathway by the HIV Auxiliary Proteins
por: Seissler, Tanja, et al.
Publicado: (2017)

Insights into the mechanisms of RNA secondary structure destabilization by the HIV-1 nucleocapsid protein
por: Belfetmi, Anissa, et al.
Publicado: (2016)

Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States
por: Mouhand, Assia, et al.
Publicado: (2020)

Blocking premature reverse transcription fails to rescue the HIV-1 nucleocapsid-mutant replication defect
por: Thomas, James A, et al.
Publicado: (2011)

Dynamics of Linker Residues Modulate the Nucleic Acid Binding Properties of the HIV-1 Nucleocapsid Protein Zinc Fingers
por: Zargarian, Loussiné, et al.
Publicado: (2014)

Retroviral RNA Dimerization: From Structure to Functions
por: Dubois, Noé, et al.
Publicado: (2018)

Post-Translational Modifications of Retroviral HIV-1 Gag Precursors: An Overview of Their Biological Role
por: Bussienne, Charlotte, et al.
Publicado: (2021)

Pan-retroviral Nucleocapsid-Mediated Phase Separation Regulates Genomic RNA Positioning and Trafficking
por: Monette, Anne, et al.
Publicado: (2020)

Mutations in the phosphorylation sites of SARS-CoV-2 encoded nucleocapsid protein and structure model of sequestration by protein 14-3-3
por: Tung, H.Y. Lim, et al.
Publicado: (2020)

Importance of the proline-rich multimerization domain on the oligomerization and nucleic acid binding properties of HIV-1 Vif
por: Bernacchi, Serena, et al.
Publicado: (2011)

Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein
por: Stupfler, Benjamin, et al.
Publicado: (2021)

Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides
por: Fisher, Robert J., et al.
Publicado: (2006)

Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides
por: Fisher, Robert J., et al.
Publicado: (2006)

HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus
por: Guerrero, Santiago, et al.
Publicado: (2015)

Intralobar sequestration
por: Arjun, Padmanabhan, et al.
Publicado: (2017)

Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein
por: Post, Klara, et al.
Publicado: (2009)

Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins
por: Cruceanu, Margareta, et al.
Publicado: (2006)

Differential contribution of basic residues to HIV-1 nucleocapsid protein’s nucleic acid chaperone function and retroviral replication
por: Wu, Hao, et al.
Publicado: (2014)

HIV-1 Nucleocapsid Protein Binds Double-Stranded DNA in Multiple Modes to Regulate Compaction and Capsid Uncoating
por: Gien, Helena, et al.
Publicado: (2022)

Nucleocapsid Assembly of Baculoviruses
por: Zhao, Shuling, et al.
Publicado: (2019)

HIV controls the selective packaging of genomic, spliced viral and cellular RNAs into virions through different mechanisms
por: Houzet, Laurent, et al.
Publicado: (2007)

HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation
por: Mercenne, Gaëlle, et al.
Publicado: (2010)

The Life-Cycle of the HIV-1 Gag–RNA Complex
por: Mailler, Elodie, et al.
Publicado: (2016)

Structural and Functional Motifs in Influenza Virus RNAs
por: Ferhadian, Damien, et al.
Publicado: (2018)

Chemical and Enzymatic Probing of Viral RNAs: From Infancy to Maturity and Beyond
por: Gilmer, Orian, et al.
Publicado: (2021)

Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition
por: Post, Klara, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2a2tp4gst5pkls3j51b47tr8up