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Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses

The gut microbiome is involved in the host’s metabolism, development, and immunity, which translates to measurable impacts on disease risk and overall health. Emerging evidence supports pulses, i.e., grain legumes, as underutilized nutrient-dense, culinarily versatile, and sustainable staple foods t...

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Autores principales: Lutsiv, Tymofiy, Weir, Tiffany L., McGinley, John N., Neil, Elizabeth S., Wei, Yuren, Thompson, Henry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625176/
https://www.ncbi.nlm.nih.gov/pubmed/34836246
http://dx.doi.org/10.3390/nu13113992
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author Lutsiv, Tymofiy
Weir, Tiffany L.
McGinley, John N.
Neil, Elizabeth S.
Wei, Yuren
Thompson, Henry J.
author_facet Lutsiv, Tymofiy
Weir, Tiffany L.
McGinley, John N.
Neil, Elizabeth S.
Wei, Yuren
Thompson, Henry J.
author_sort Lutsiv, Tymofiy
collection PubMed
description The gut microbiome is involved in the host’s metabolism, development, and immunity, which translates to measurable impacts on disease risk and overall health. Emerging evidence supports pulses, i.e., grain legumes, as underutilized nutrient-dense, culinarily versatile, and sustainable staple foods that promote health benefits through modulating the gut microbiota. Herein, the effects of pulse consumption on microbial composition in the cecal content of mice were assessed. Male mice were fed an obesogenic diet formulation with or without 35% of the protein component comprised by each of four commonly consumed pulses—lentil (Lens culinaris L.), chickpea (Cicer arietinum L.), common bean (Phaseolus vulgaris L.), or dry pea (Pisum sativum L.). Mice consuming pulses had distinct microbial communities from animals on the pulse-free diet, as evidenced by β-diversity ordinations. At the phylum level, animals consuming pulses showed an increase in Bacteroidetes and decreases in Proteobacteria and Firmicutes. Furthermore, α-diversity was significantly higher in pulse-fed animals. An ecosystem of the common bacteria that were enhanced, suppressed, or unaffected by most of the pulses was identified. These compositional changes are accompanied by shifts in predicted metagenome functions and are concurrent with previously reported anti-obesogenic physiologic outcomes, suggestive of microbiota-associated benefits of pulse consumption.
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spelling pubmed-86251762021-11-27 Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses Lutsiv, Tymofiy Weir, Tiffany L. McGinley, John N. Neil, Elizabeth S. Wei, Yuren Thompson, Henry J. Nutrients Article The gut microbiome is involved in the host’s metabolism, development, and immunity, which translates to measurable impacts on disease risk and overall health. Emerging evidence supports pulses, i.e., grain legumes, as underutilized nutrient-dense, culinarily versatile, and sustainable staple foods that promote health benefits through modulating the gut microbiota. Herein, the effects of pulse consumption on microbial composition in the cecal content of mice were assessed. Male mice were fed an obesogenic diet formulation with or without 35% of the protein component comprised by each of four commonly consumed pulses—lentil (Lens culinaris L.), chickpea (Cicer arietinum L.), common bean (Phaseolus vulgaris L.), or dry pea (Pisum sativum L.). Mice consuming pulses had distinct microbial communities from animals on the pulse-free diet, as evidenced by β-diversity ordinations. At the phylum level, animals consuming pulses showed an increase in Bacteroidetes and decreases in Proteobacteria and Firmicutes. Furthermore, α-diversity was significantly higher in pulse-fed animals. An ecosystem of the common bacteria that were enhanced, suppressed, or unaffected by most of the pulses was identified. These compositional changes are accompanied by shifts in predicted metagenome functions and are concurrent with previously reported anti-obesogenic physiologic outcomes, suggestive of microbiota-associated benefits of pulse consumption. MDPI 2021-11-09 /pmc/articles/PMC8625176/ /pubmed/34836246 http://dx.doi.org/10.3390/nu13113992 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lutsiv, Tymofiy
Weir, Tiffany L.
McGinley, John N.
Neil, Elizabeth S.
Wei, Yuren
Thompson, Henry J.
Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_full Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_fullStr Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_full_unstemmed Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_short Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_sort compositional changes of the high-fat diet-induced gut microbiota upon consumption of common pulses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625176/
https://www.ncbi.nlm.nih.gov/pubmed/34836246
http://dx.doi.org/10.3390/nu13113992
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