HIV-1 Envelope Glycoproteins Proteolytic Cleavage Protects Infected Cells from ADCC Mediated by Plasma from Infected Individuals

The HIV-1 envelope glycoprotein (Env) is synthesized in the endoplasmic reticulum as a trimeric gp160 precursor, which requires proteolytic cleavage by a cellular furin protease to mediate virus-cell fusion. Env is conformationally flexible but controls its transition from the unbound “closed” confo...

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Detalles Bibliográficos
Autores principales: Prévost, Jérémie, Medjahed, Halima, Vézina, Dani, Chen, Hung-Ching, Hahn, Beatrice H., Smith, Amos B., Finzi, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625184/
https://www.ncbi.nlm.nih.gov/pubmed/34835042
http://dx.doi.org/10.3390/v13112236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625184/
https://www.ncbi.nlm.nih.gov/pubmed/34835042
http://dx.doi.org/10.3390/v13112236

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