Exposure of Von Willebrand Factor Cleavage Site in A1A2A3-Fragment under Extreme Hydrodynamic Shear

Von Willebrand Factor (vWf) is a giant multimeric extracellular blood plasma involved in hemostasis. In this work we present multi-scale simulations of its three-domains fragment A1A2A3. These three domains are essential for the functional regulation of vWf. Namely the A2 domain hosts the site where...

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Detalles Bibliográficos
Autores principales: Languin-Cattoën, Olivier, Laborie, Emeline, Yurkova, Daria O., Melchionna, Simone, Derreumaux, Philippe, Belyaev, Aleksey V., Sterpone, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625202/
https://www.ncbi.nlm.nih.gov/pubmed/34833213
http://dx.doi.org/10.3390/polym13223912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625202/
https://www.ncbi.nlm.nih.gov/pubmed/34833213
http://dx.doi.org/10.3390/polym13223912

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